RTK signalling: from mouse development & pathologies
to new molecular therapies

2011
A. Furlan, F. Colombo, A. Kover, N. Issaly, C. Tintori, L. Angeli, S. Letard, V. Leroux, M. Amat, B. Maigret, P. Dubreuil, M. Botta, R. Dono, J. Bosch, O. Piccolo, D. Passarella and F. Maina. Identification of new aminoacid amides containing the imidazo[2,1-b]benzothiazol-2-ylphenyl moiety as inhibitor of tumorigenesis by oncogenic Met signaling. European Journal of Medicinal Chemistry, in press (2011).

F. Lamballe, M. Genestine, N. Caruso, V. Arce, S. Richelme, F. Helmbacher* and F. Maina*. Pool-specific regulation of motor neuron survival by neurotrophic support. J. Neuroscience 31(31):11144-58 (2011).

I. del Barco Barrantes, J.M. Coya, F. Maina, J.S.C. Arthur and A.R. Nebreda. Genetic analysis of specific and redundant roles for p38? and p38? MAPKs during mouse development. PNAS 108(31):12764-9 (2011).

M. Perrinjaquet, D. Sjöstrand, A. Moliner, S. Zechel, F. Lamballe, F. Maina and C. F. Ibáñez. Met signaling in GABAergic neurons of the medial ganglionic eminence restricts GDNF activities in cells expressing GFRalpha1 and a novel transmembrane receptor. J. of Cell Science 124(Pt 16):2797-805 (2011).

A. Furlan, V. Stagni, A. Hussain, S. Richelme, F. Conti, A. Prodosmo, A. Destro, M. Roncalli, D. Barilà* and F. Maina*. Abl interconnects oncogenic Met and p53 core pathways in cancer cells. Cell Death & Differentiation doi:10.1038/cdd.2011.23 (2011).
 
M. Genestine, E. Caricati, A. Fico, S. Richelme, H. Hassani, C. Sunyach, F. Lamballe, G.C. Panzica, B. Pettmann, F. Helmbacher, C. Raoul, F. Maina* and R. Dono*. Enhanced neuronal Met signalling levels in ALS mice delay disease onset. Cell Death & Disease 17;2:e130 (2011).

L. Tönges, T. Ostendorf, F. Lamballe, M. Genestine, R. Dono, J.C. Koch, M. Bähr, F. Maina* and P. Lingor*. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J. Neurochemistry 117(5): 892-903 (2011).

2010
E. Gascon, S. Gaillard, P. Malapert, Y. Liu, F. Helmbacher, F. Maina and A. Moqrich. Hepatocyte Growth Factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J. Neuroscience 30(37):12414 –12423 (2010).

E. Krejci, M. Grim, F. Maina, Y. Shwartz, A. Otto, R. Huang and K. Patel. Somitic origin of the medial border of the mammalian scapula and its homology to the avian scapula blade. J. of Anatomy 216(4):482-8 (2010).

2009
Y. Asses, V. Leroux, S. Tairi-Kellou, R. Dono, F. Maina and B. Maigret. Analysis of c-Met kinase domain complexes: a new specific catalytic site receptor model for defining binding modes of ATP-competitive ligands. Chemical Biology & Drug Design. 74(6): 560-570 (2009).
 
2008
S. Patané, N. Pietrancosta, H. Hassani, V. Leroux, B. Maigret, J.L. Kraus, R. Dono and F. Maina. A new Met inhibitory-scaffold identified by a focused forward chemical biological screen. Biochem. Biophys. Res. Commun. 375:184-9 (2008).

2007
A. Moumen, S. Patané, A. Porras, R. Dono and F. Maina. mTOR acts through Mdm2 to signal cell survival in vivo. Development 134:1443-51 (2007).
 
A. Moumen, A. Ieraci, S. Patané, C. Solé, J. Comella, R.Dono and F. Maina. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3K/Akt dependent manner. Hepatology 45: 1210-7 (2007).

P. Fazzari, J. Penachioni, S. Gianola, F. Rossi, B.J. Eickholt, F. Maina, L. Alexopoulou, A. Sottile, P.M. Comoglio, R.A. Flavell and L. Tamagnone. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. BMC Dev Biol. 7:55-67 (2007).

G. Luxardi, A.Galli, S. Forlani, K. Lawson, F. Maina and R. Dono. Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Biochem. Biophys. Res. Commun. 352: 55-60 (2007).

2006
N. Pietrancosta, A. Moumen, R. Dono, P. Lingor, V. Planchamp, F. Lamballe, M. Bähr, J.L. Kraus* and F. Maina*. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J. Med. Chem. 49: 3645-52 (2006).
 
J. Segarra, L. Balenci, T. Drenth, F. Maina* and F. Lamballe*. Combined signaling through ERKs, PI3K/Akt and Rac1/p38 is required for Met-triggered cortical neuron migration. J. Biol. Chem. 281: 4771-8 (2006). This article was selected as a Paper of the Week.
 
2005
G. Pante, J. Thompson, F. Lamballe, T. Iwata, F.A. Barr, A.M. Davies, F. Maina and R. Klein. Mitogen-inducible-gene-6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. J. Cell Biol. 171: 337-48 (2005).
 
N. Pietrancosta, F. Maina, R. Dono, A. Moumen, C. Garino, S. Burlet, G. Quéléver and J.L. Kraus. Novel cyclised Pifithrin-a p53 inactivators: synthesis and biological studies. Bioorganic and molecular chemistry letters 15: 1561-4 (2005).
 
P. Valasek, D.J.R. Evans, F. Maina, M. Grim and K. Patel. A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells. Development 132: 447-58 (2005).
 
2004
D. Tulasne, J. Deheuninck, F.C. Lourenço, F. Lamballe, Z. Ji, C. Leroy, E. Puchois, A. Moumen, F. Maina, P. Mehlen and V. Fafeur. Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Molecular and Cellular Biology 24(23): 10328-39 (2004).
 
2003
F. Helmbacher, E. Dessaud, S. Arber, O. deLapeyrière, C. Henderson, R. Klein and F. Maina. Met signaling is required for recruitment of motor neurons to Pea3-positive motor pools. Neuron 39, 767-77 (2003).
 
2001
F. Maina, G. Pante’, F. Helmbacher, A. Renvaktar, R. Andres, A.M. Davies, C. Ponzetto, and R. Klein. Coupling Met to specific pathways results in distinct developmental outcomes. Molecular Cell 7, 1293-306 (2001).