RTK signalling: from mouse development & pathologies
to new molecular therapies

S. Patané, N. Pietrancosta, H. Hassani, V. Leroux, B. Maigret, J.L. Kraus, R. Dono and F. Maina. A new Met inhibitory-scaffold identified by a focused forward chemical biological screen. BBRC, in press.

A. Moumen, S. Patané, A. Porras, R. Dono and F. Maina. mTOR acts through Mdm2 to signal cell survival in vivo. Development 134:1443-51 (2007).

A. Moumen, A. Ieraci, S. Patané, C. Solé, J. Comella, R.Dono and F. Maina. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3K/Akt dependent manner. Hepatology 45: 1210-7 (2007).

P. Fazzari, J. Penachioni, S. Gianola, F. Rossi, B.J. Eickholt, F. Maina, L. Alexopoulou, A. Sottile, P.M. Comoglio, R.A. Flavell and L. Tamagnone. Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis. BMC Dev Biol. 7:55-67 (2007).

G. Luxardi, A.Galli, S. Forlani, K. Lawson, F. Maina and R. Dono. Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Biochem. Biophys. Res. Commun. 352: 55-60 (2007).

N. Pietrancosta, A. Moumen, R. Dono, P. Lingor, V. Planchamp, F. Lamballe, M. Bähr, J.L. Kraus and F. Maina. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J. Med. Chem. 49: 3645-52 (2006).

J. Segarra, L. Balenci, T. Drenth, F. Maina and F. Lamballe. Combined signaling through ERKs, PI3K/Akt and Rac1/p38 is required for Met-triggered cortical neuron migration. J. Biol. Chem. 281: 4771-8 (2006).

G. Pante, J. Thompson, F. Lamballe, T. Iwata, F.A. Barr, A.M. Davies, F. Maina and R. Klein. Mitogen-inducible-gene-6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. J. Cell Biol. 171: 337-48 (2005).

N. Pietrancosta, F. Maina, R. Dono, A. Moumen, C. Garino, S. Burlet, G. Quéléver and J.L. Kraus. Novel cyclised Pifithrin-a p53 inactivators: synthesis and biological studies. Bioorganic and molecular chemistry letters 15: 1561-4 (2005).

P. Valasek, D.J.R. Evans, F. Maina, M. Grim and K. Patel. A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells. Development 132: 447-58 (2005).

D. Tulasne, J. Deheuninck, F.C. Lourenço, F. Lamballe, Z. Ji, C. Leroy, E. Puchois, A. Moumen, F. Maina, P. Mehlen and V. Fafeur. Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Molecular and Cellular Biology 24(23): 10328-39 (2004).

F. Helmbacher, E. Dessaud, S. Arber, O. deLapeyrière, C. Henderson, R. Klein and F. Maina. Met signaling is required for recruitment of motor neurons to Pea3-positive motor pools. Neuron 39, 767-77 (2003).

F. Maina, G. Pante’, F. Helmbacher, A. Renvaktar, R. Andres, A.M. Davies, C. Ponzetto, and R. Klein. Coupling Met to specific pathways results in distinct developmental outcomes. Molecular Cell 7, 1293-306 (2001).